1252-1254 He LAJP 3384:He
نویسندگان
چکیده
Drug-drug interaction and herb-drug interaction have been frequently reported when patients take propofol in combination with other important clinical drugs or herbs. Intestinal bacteria-catalyzed biotransformation process might significantly change the properties of compounds, such as the efficiency, toxicity, and the pharmacokinetic behaviours. The present study aims to investigate whether the intestinal bacteria that catalyzed biotransformation of glucoaurantio-obtusin can influence the inhibitory capability towards the metabolism of the hypnotic agent, and propofol was selected as the example. The results showed that aurantio-obtusin exhibited stronger inhibition than glucoaurantio-obtusin towards propofol glucuronidation at various tested concentrations. Furthermore, the noncompetitive inhibition of aurantio-obtusin towards propofol glucuronidation was demonstrated, and the inhibition parameter (Ki) was calculated to be 78.7 μM. All these information will be helpful to understand the clinical safety when propofol is co-administered with herbs.
منابع مشابه
Op-ijej140035 1252..1262
Background: Chinese women’s reproductive patterns have changed significantly over the past several decades. However, relatively little is known about the pace and characteristics of these changes either overall or by region and socioeconomic status. Methods: We examined the cross-sectional data from the China Kadoorie Biobank cohort study that recruited 300 000 women born between 1930 and 1974 ...
متن کاملInvestigating the possibility of some Arabs following Mazdakism in the pre-Islamic period
Ibn al-Kalbī in the Mathālib al-'Arab reports the emergence of Zindīq among Qurayshs while introducing the religions existing among Arab tribes and states that the Christians of al-Hirah taught the Zindīq to the Qurayshs’ merchants. He also mentioned the names of the Zindīqs of Quraysh. According to the historical evidence of using Zindīq in the meaning of Mazdakism, the question of this articl...
متن کاملRecovery from an eighty-percent total body surface area burn injury sustained at work.
This article presents a case of severe burn injury at work involving 80 % of body surface area and patient treatment and rehabilitation, which resulted in preserved working ability. The worker was injured by hot water and steam. After initial treatment in the intensive care unit, he underwent comprehensive clinical and outpatient rehabilitation that took 92 weeks, after which he returned to wor...
متن کاملStrain-specific enhancement or inhibition of coumarin hepatotoxicity in mice following pretreatment with two different liver enzyme-inducing agents.
Human exposure to coumarin continues despite controversy over its hepatotoxic potential. Greater understanding of human reactions to coumarin may be achieved by studying murine interstrain differences. The metabolic basis of coumarin hepatotoxicity and its modulation by liver enzyme inducers, beta-naphthoflavone (beta NF) and aroclor 1254 (ARO), were investigated in C3H/He and DBA/2 mice. Couma...
متن کاملReport on a packaged handwashing antiseptic contaminated with Pseudomonas aeruginosa.
REFERENCES 1. Council Directive 80/778/EEC [European Economic Community] concerning the quality of drinking water intended for human consumption. July 15,1980. 2. Martin MV. The significance of the bacterial contamination of dental unit water systems. Br Dent J 1987;163:152-154. 3. Williams JF, Huntington MK, Johnston AM. Dental waterlines. A source of contamination. Infection Control and Steri...
متن کامل